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Nicotine & Tobacco Research Advance Access published online on April 7, 2009
Nicotine & Tobacco Research, doi:10.1093/ntr/ntp042
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© The Author 2009. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Combination treatment with varenicline and nicotine replacement therapy

Jon O. Ebbert, Michael V. Burke, J. Taylor Hays and Richard D. Hurt

Jon O. Ebbert, M.D., M.Sc., Mayo Clinic College of Medicine, Rochester, MN
Michael V. Burke, Ed.D., Mayo Clinic College of Medicine, Rochester, MN
J. Taylor Hays, M.D., Mayo Clinic College of Medicine, Rochester, MN
Richard D. Hurt, M.D., Mayo Clinic College of Medicine, Rochester, MN

Corresponding Author:Jon O. Ebbert, M.D., M.Sc., Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA. Telephone: 507-266-1944. Fax: 507-266-7900. Email: ebbert.jon{at}mayo.edu


  Abstract

Introduction: A paucity of data exists regarding the safety and effectiveness of combination treatment with varenicline and nicotine replacement therapy (NRT).

Methods: We reviewed the clinical experience of two groups of cigarette smokers enrolled in a residential tobacco treatment program: (a) patients receiving combination treatment with varenicline and NRT (N = 104) and (b) usual-care patients receiving treatment before the release of varenicline (N = 135).

Results: Demographic characteristics were similar between the two groups. Among smokers receiving varenicline and NRT, 71% used the nicotine patch with a mean dose of 32 mg/day (SD = 14) and 73% used at least two types of NRT. Adverse events were experienced by 39% (95% CI = 31%–49%) of patients receiving varenicline and NRT and by 59% (95% CI = 51%–67%) of usual-care patients during the residential program. A total of five patients (5%) discontinued varenicline due to adverse events, compared with one patient in the usual-care group. We did not observe a significant difference in the 30-day point prevalence smoking abstinence rate at 6 months between patients treated with varenicline and NRT (54%; 95% CI = 44%–64%) and usual-care patients (59%; 95% CI = 50%–66%).

Discussion: Our findings suggest that combination therapy with varenicline and NRT is safe and well tolerated among patients in a residential tobacco treatment program.

Received: June 23, 2008; Accepted: November 8, 2008
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