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Nicotine & Tobacco Research 2009 11(3):221-224; doi:10.1093/ntr/ntp070
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© The Author 2009. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

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Richard Hébert

The first 150 words of the full text of this article appear below.


   Smoking while pregnant: Genes play a role
 
Up to half of pregnant smokers manage to quit or cut back. Genetic variations may play a role, especially those that encode enzymes that change the toxicity of tobacco-related chemicals in the body. Prime candidates are variants of CYP1A1 and the absence of GSTM1.

Chen et al. (p. 225) investigated whether women with these genetic variants were more likely to quit or reduce their smoking because the increased accumulations of tobacco-related toxic chemicals in their bodies discourage smoking. They took DNA swabs from 158 smoking mothers of children aged 6 to 9 and asked about their smoking behaviors during pregnancy.

  • Those who had one of several variants of CYP1A1 were more likely to have quit or cut back while pregnant.
  • Those who had both the non-variant gene and GSTM1 were less likely to have quit or cut back.

The finding suggests genetic factors should play "a role...in . . . [Full Text of this Article]


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