Nicotine & Tobacco Research 2009 11(4):338-341; doi:10.1093/ntr/ntp071
© The Author 2009. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
What's new in Nicotine & Tobacco Research?
Richard Hébert
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Inhaling nicotine for fast relief
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Fast-acting nicotine inhalers could help addicted smokers who
relapse after trying other quit-smoking aids by offering them
a second-line alternative that more closely mimicks smoking.
In New Zealand, Caldwell et al. (p. 342) pilot-tested a metered-dose inhaler on 10 smokers, first with 10 puffs of 50 micrograms of nicotine per puff, then with double that dosage.
- Peak nicotine levels were higher and reached more rapidly than is typical of other nicotine replacements, including nasal sprays.
- Smokers said the inhalers were as satisfying as their usual cigarettes, even though peak nicotine levels in the blood were half those of cigarettes and took three times longer to peak.
- The 50-microgram inhaler most closely resembled cigarettes in reducing the urge to smoke.
For the first few puffs, especially at the higher dosage, inhalers caused coughing and interrupted smooth inhalation, but smokers "accepted it reasonably well," the investigators report. Although a larger, . . . [Full Text of this Article]
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