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Nicotine & Tobacco Research Advance Access published online on November 23, 2009

Nicotine & Tobacco Research, doi:10.1093/ntr/ntp167
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© The Author 2009. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Smoking abstinence and reinstatement effects in adolescent cigarette smokers

Suzanne M. Colby, Adam M. Leventhal, Linda Brazil, Johanna Lewis-Esquerre, L. A. R. Stein, Damaris J. Rohsenow, Peter M. Monti and Raymond S. Niaura

Suzanne M. Colby, Ph.D., Department of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, RI
Adam M. Leventhal, Ph.D., Department of Community Health, Center for Alcohol and Addiction Studies, Brown University, Providence, RI
Linda Brazil, M.S., Center for Alcohol and Addiction Studies, Brown University, Providence, RI
Johanna Lewis-Esquere, Ph.D., Center for Alcohol and Addiction Studies, Brown University, Providence, RI
Damaris J. Rohsenow, Ph.D., Providence Veterans Affairs Medical Center, Department of Community Health, Center for Alcohol and Addiction Studies, Brown University, Providence, RI
L. A. R. Stein, Ph.D., Psychology Department, University of Rhode Island, Kingston, RI
Peter M. Monti, Ph.D., Providence Veterans Affairs Medical Center, Department of Community Health, Center for Alcohol and Addiction Studies, Brown University, Providence, RI
Raymond S. Niaura, Ph.D., Transdisciplinary Research Program, Butler Hospital, Providence, RI, and Department of Psychiatry and Human Behavior, Brown University, Providence RI

Corresponding Author:Suzanne M. Colby, Ph.D., Brown University, Center for Alcohol and Addiction Studies, Providence, RI 02912, USA. Telephone: 401-863-6655; Fax: 401-863-6697; E-mail: Suzanne_Colby{at}brown.edu


   Abstract

Introduction: The study objectives were to examine smoking abstinence and reinstatement effects on subjective experience and cognitive performance among adolescent smokers.

Methods: Adolescents (aged 14–17 years, 60 daily smokers and 32 nonsmokers) participated. Participants completed baseline assessments (Session 1) and returned to the laboratory 1–3 days later to repeat assessments (Session 2); half of the smokers were randomly assigned to 15–17 hr tobacco abstinence preceding Session 2.

Results: During Session 2, abstaining smokers reported significantly greater increases in withdrawal symptoms, smoking urges, and negative affect compared with smokers who did not abstain and compared with nonsmokers. Smoking reinstatement reversed abstinence effects, returning to baseline levels for smoking urges and negative affect. Abstaining smokers showed significantly enhanced cognitive performance on two of six tasks (two-letter search compared with nonabstaining smokers; serial reaction time compared with nonsmokers); smoking reinstatement resulted in significant decrements on these two tasks relative to nonabstaining smokers.

Discussion: Effects of smoking abstinence and reinstatement on self-report measures are consistent with earlier research with adolescent as well as adult smokers and may help to elucidate the motivational underpinnings of smoking maintenance among adolescent smokers. Effects found on cognitive performance were contrary to hypotheses; further research is needed to understand better the role of cognitive performance effects in smoking maintenance among adolescents.

Received: April 10, 2009; Revised: September 1, 2009; Accepted: October 13, 2009
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