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Nicotine & Tobacco Research Advance Access published online on March 23, 2009
Nicotine & Tobacco Research, doi:10.1093/ntr/ntn034
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© The Author 2009. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Examination of the Nicotine Dependence (NICSNP) Consortium findings in the Iowa adoption studies population

Robert A. Philibert, Alexandre Todorov, Allan Andersen, Nancy Hollenbeck, Tracy Gunter, Andrew Heath and Pamela Madden

Robert A. Philibert, M.D., Ph.D., Department of Psychiatry and Neuroscience and Genetics Programs, University of Iowa, Iowa City, IA
Alexandre Todorov, Ph.D., Department of Psychiatry, Washington University of St. Louis, St. Louis, MO
Allan Andersen, M.D., Georgetown University, Washington, DC
Nancy Hollenbeck, M.A., Department of Psychiatry, University of Iowa, Iowa City, IA
Tracy Gunter, M.D., Department of Psychiatry, University of Iowa, Iowa City, IA
Andrew Heath, Ph.D., Department of Psychiatry, Washington University of St. Louis, St. Louis, MO
Pamela Madden, Ph.D., Department of Psychiatry, Washington University of St. Louis, St. Louis, MO

Corresponding Author: Robert A. Philibert, M.D., Ph.D., Department of Psychiatry, Rm 2-126 MEB, University of Iowa, Iowa City, IA 52242, USA. Telephone: 319-353-4986. Fax: 301-353-3003. Email: robert-philibert{at}uiowa.edu


  Abstract

Introduction: Nicotine dependence results from a complex interplay of genetic and environmental factors. Over the past several years, a large number of studies have been performed to identify distinct gene loci containing genetic vulnerability to nicotine dependence. Two of the most prominent studies were conducted by the Collaborative Study of the Genetics of Nicotine Dependence (NICSNP) Consortium using both candidate gene and high-density association approaches.

Methods: We attempted to confirm and extend the most significant findings from the high-density association study and the candidate gene study using the behavioral and genetic resources of the Iowa Adoption Studies, the largest case–control adoption study of substance use in the United States.

Results: We found evidence that genetic variation at CHRNA1, CHRNA2, CHRNA7, and CHRNB1 alters susceptibility to nicotine dependence, but we did not replicate any of the most significant single nucleotide polymorphism associations from the NICSNP high-density association study.

Discussion: Further examination of the NICSNP findings in other population samples is indicated.

Received: March 13, 2008; Accepted: September 16, 2008
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