Skip Navigation


Nicotine & Tobacco Research Advance Access originally published online on July 2, 2009
Nicotine & Tobacco Research 2009 11(10):1142-1153; doi:10.1093/ntr/ntp111
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Article Summary
Right arrow All Versions of this Article:
11/10/1142    most recent
ntp111v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Strong, D. R.
Right arrow Articles by Brown, R. A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strong, D. R.
Right arrow Articles by Brown, R. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Impact of bupropion and cognitive–behavioral treatment for depression on positive affect, negative affect, and urges to smoke during cessation treatment

David R. Strong, Christopher W. Kahler, Adam M. Leventhal, Ana M. Abrantes, Elizabeth Lloyd-Richardson, Raymond Niaura and Richard A. Brown

David R. Strong, Ph.D., Warren Alpert Medical School of Brown University and Butler Hospital, Providence, RI
Christopher W. Kahler, Ph.D., Warren Alpert Medical School of Brown University, Providence, RI
Adam M. Leventhal, Ph.D., Warren Alpert Medical School of Brown University, Providence, RI
Ana M. Abrantes, Ph.D., Warren Alpert Medical School of Brown University and Butler Hospital, Providence, RI
Elizabeth Lloyd-Richardson, Ph.D., Warren Alpert Medical School of Brown University, Providence, RI
Raymond Niaura, Ph.D., Warren Alpert Medical School of Brown University and Butler Hospital, Providence, RI
Richard A. Brown, Ph.D., Warren Alpert Medical School of Brown University and Butler Hospital, Providence, RI

Corresponding Author: David R. Strong, Ph.D., Butler Hospital, Warren Alpert Medical School of Brown University, 345 Blackstone Boulevard, Providence, RI 02906, USA. Telephone: 401-455-6294; Fax: 401-455-6424; E-mail: david_strong{at}brown.edu


  Abstract

Introduction: Bupropion and cognitive–behavioral treatment (CBT) for depression have been used as components of treatments designed to alleviate affective disturbance during smoking cessation. Studies of treatment-related changes in precessation affect or urges to smoke are needed to evaluate the proposed mechanisms of these treatments.

Methods: The present report examines affective trajectories and urges to smoke prior to, on quit day, and after quitting in a sample of 524 smokers randomized to receive bupropion versus placebo and CBT versus standard smoking cessation CBT.

Results: Bupropion and/or CBT did not affect the observed decreases in positive affect and increases in negative affect prior to cessation. However, on quit day, observed levels of negative affect and urges to smoke were diminished significantly among individuals receiving bupropion. Decreases in positive affect prior to quitting, lower levels of positive affect, and increased levels of negative affect and urges to smoke on quit day were each related to higher risk of smoking lapse. Depression proneness was an independent predictor of lower positive affect and higher negative affect but did not moderate the effects of bupropion on outcomes. In mediational analyses, the effect of bupropion was accounted for in part by lower negative affect and urges to smoke on quit day.

Discussion: Results support the efficacy of bupropion in reducing relapse risk associated with urges to smoke and negative affect and suggest the need to better understand the role of low positive affect as a risk factor for early lapse.

Received: July 9, 2008; Accepted: January 1, 2009
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.